Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-
existing blood vessels. The process of development of the proper vascular network is a …