Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …
JH Driskill, D Pan - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Complex physiological processes control whether stem cells self-renew, differentiate or remain quiescent. Two decades of research have placed the Hippo pathway, a highly …
IM Moya, G Halder - Nature reviews Molecular cell biology, 2019 - nature.com
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes- associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
The Hippo signalling pathway has emerged as a major player in many aspects of liver biology, such as development, cell fate determination, homeostatic function and …
A Totaro, T Panciera, S Piccolo - Nature cell biology, 2018 - nature.com
Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
X Cai, KC Wang, Z Meng - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and homeostasis. During organ development and tissue injury repair, compressive and tensional …
Y Zheng, D Pan - Developmental cell, 2019 - cell.com
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here …
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
GTK Boopathy, W Hong - Frontiers in cell and developmental biology, 2019 - frontiersin.org
Angiogenesis is a highly coordinated process of formation of new blood vessels from pre- existing blood vessels. The process of development of the proper vascular network is a …