Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

Conventional antidepressants that target monoaminergic receptors require several weeks to
be efficacious. This lag represents a significant problem in the currently available treatments …

Ketamine is shown to enhance excitatory synaptic drive in multiple brain areas, which is
presumed to underlie its rapid antidepressant effects. Moreover, ketamine's therapeutic …

The discovery that subanesthetic doses of (R, S)-ketamine (ketamine) and (S)-ketamine
(esketamine) rapidly induce antidepressant effects and promote sustained actions following …

Anorexia nervosa is a disorder associated with serious adverse health outcomes, for which
there is currently considerable treatment ineffectiveness. Characterised by restrictive eating …

Ketamine has emerged as an effective option for treatment-resistant depression (TRD), with
a quick and long-lasting antidepressant effect, as well as anti-suicidal benefits. This …

The dysregulation of excitatory and inhibitory neurotransmission is considered a
pathological marker of Anorexia Nervosa (AN), however, no systematic evaluation of the …

Interactions between neurons and cancer cells are found in many malignancies, but their
relevance for metastatic organ colonization remain largely unknown. It is also unclear …

Ketamine, a dissociative anesthetic primarily recognized for its antagonism of N-methyl-D-
aspartate (NMDA) receptors, has gained significant attention for its rapid antidepressant …

Ketamine is shown to enhance excitatory synaptic drive in the hippocampus, which is
presumed to underlie its rapid antidepressant effects. Moreover, ketamine's therapeutic …