Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …

Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …

Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX
genes. Recent studies have implicated histone methylation in long-term gene silencing …

Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

Enhancer of Zeste is a Polycomb Group protein essential for the establishment and
maintenance of repression of homeotic and other genes. In the early embryo it is found in a …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous
developmental genes. To silence or activate gene expression, respectively, PcG and trxG …

MLL, the human homolog of Drosophila trithorax, maintains Hox gene expression in
mammalian embryos and is rearranged in human leukemias resulting in Hox gene …