Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of
morbidity and mortality in countries around the world. Atherosclerosis combines the …

Plaque rupture, usually of a precursor lesion known as a'vulnerable plaque'or'thin-cap
fibroatheroma', is the leading cause of thrombosis. Less-frequent aetiologies of coronary …

Expert recommendations on the assessment of wall shear stress in human coronary arteries:
existing methodologies, technical considerations, and clinical applications | European Heart …

Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall
(radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress) …

Atherosclerotic plaque rupture with luminal thrombosis is the most common mechanism
responsible for the majority of acute coronary syndromes and sudden coronary death. The …

Background Experimental studies suggest that low wall shear stress (WSS) promotes
plaque development and high WSS is associated with plaque destabilization. We …

Today's concept of vulnerable plaque has evolved primarily from the early pioneering work
uncovering the pivotal role of plaque rupture and coronary thrombosis as the major cause of …

Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion
that shows calcification is pathologic intimal thickening in which calcifications appear as …

Background—Atherosclerotic plaques progress in a highly individual manner. The purposes
of the Prediction of Progression of Coronary Artery Disease and Clinical Outcome Using …