On the 400th anniversary of Harvey's Lumleian lectures, this review focuses on
“hemodynamic” forces associated with the movement of blood through arteries in humans …

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic,,,,. Studies of sensory neurons …

It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes
injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a …

Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which
may be independent of physical activity. To date, the mechanism (s) that mediate this …

abstract Epithelial cells experience constant mechanical forces, including fluid shear stress
(FSS) on their apical surface. These forces alter both structure and function. While precise …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

The endothelium that lines the interior of blood vessels is directly exposed to blood flow. The
shear stress arising from blood flow is “sensed” by the endothelium and is “transduced” into …

Metabolic syndrome (MetS) is a collection of pathological conditions associated with
metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the …

G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but
also serve as mechanosensors involved in various (patho) physiological settings like …