Abstract Diosmin (diosmetin-7-O-rutinoside) and its aglycone diosmetin, natural
bioflavonoids distributing in a variety of citrus fruits and Chinese herbal medicines …

Malignant melanoma is a high-grade aggressive skin tumor with an increasing incidence
and mortality rates worldwide. Chemotherapeutic drugs such as doxorubicin have limited …

Lonicerae japonicae flos.(LJF) was widely used as a drug to treat upper respiratory tract
infection or a tea to clear heat in Asian countries for thousands of years. Despite of its …

Therapeutic agents can be transformed into reactive metabolites under the action of various
metabolic enzymes in vivo and then covalently combine with biological macromolecules …

Naringin has been documented to possess various bioactivities. Due to thorny endogenous
interferences, the metabolism pathways of naringin and exact amounts of derived phenolic …

Naoxintong Capsule (NXTC) is a well-known Traditional Chinese Medicine (TCM)
medication that has been widely employed in the treatment of cardiovascular and …

Abstract Traditional Chinese medicines (TCMs) usually contained a large number of
chemical components, which could be transformed into more complex metabolites in vivo. In …

Abstract San Miao Wan (SMW), composed of Phellodendri Chinensis Cortex, Atractylodis
Lanceae Rhizoma and Achyranthis Bidentatae Radix, is widely used for the treatment of …

Genipin, an aglycone of geniposide, is a rich iridoid component in the fruit of Gardenia
jasminoides Ellis and has numerous biological activities. However, its metabolic profiles in …

Polydatin is one of the main bioactive constituents isolated from Polygonum cuspidatum
Sieb. et Zucc., which possesses various pharmacological activities. In this study, we …