Deuterium metabolic imaging–Back to the future

HM De Feyter, RA de Graaf - Journal of Magnetic Resonance, 2021 - Elsevier
Deuterium metabolic spectroscopy (DMS) and imaging (DMI) have recently been described
as simple and robust MR-based methods to map metabolism with high temporal and/or …

Interleaved and simultaneous multi‐nuclear magnetic resonance in vivo. Review of principles, applications and potential

AL Lopez Kolkovsky, PG Carlier, B Marty… - NMR in …, 2022 - Wiley Online Library
Magnetic resonance signals from different nuclei can be excited or received at the same
time, rendering simultaneous or rapidly interleaved multi‐nuclear acquisitions feasible. The …

Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy

M Lu, XH Zhu, Y Zhang, G Mateescu… - Journal of Cerebral …, 2017 - journals.sagepub.com
Quantitative assessment of cerebral glucose consumption rate (CMRglc) and tricarboxylic
acid cycle flux (VTCA) is crucial for understanding neuroenergetics under …

Machine learning-enabled high-resolution dynamic deuterium MR spectroscopic imaging

Y Li, Y Zhao, R Guo, T Wang, Y Zhang… - IEEE transactions on …, 2021 - ieeexplore.ieee.org
Deuterium magnetic resonance spectroscopic imaging (DMRSI) has recently been
recognized as a potentially powerful tool for noninvasive imaging of brain energy …

Noninvasive assessment of myocardial energy metabolism and dynamics using in vivo deuterium MRS imaging

T Wang, XH Zhu, H Li, Y Zhang, W Zhu… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose The assessment of cellular energy metabolism is crucial for understanding
myocardial physiopathology. Here, we conducted a pilot study to develop an alternative …

Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclear 2H, 17O and 31P MRS at ultra-high field

XH Zhu, M Lu, W Chen - Journal of Magnetic Resonance, 2018 - Elsevier
Brain energy metabolism relies predominantly on glucose and oxygen utilization to generate
biochemical energy in the form of adenosine triphosphate (ATP). ATP is essential for …

Dual‐frequency resonant coil design for low‐γ X‐nuclear and proton magnetic resonance imaging at ultrahigh fields

G Zhang, W Zhu, X Li, XH Zhu, W Chen - NMR in Biomedicine, 2023 - Wiley Online Library
Low‐γ X‐nuclear MRS and imaging have played a key role in studying metabolism and
physiopathology, especially at ultrahigh fields. We design and demonstrate a novel and …

In vivo assessment of β‐hydroxybutyrate metabolism in mouse brain using deuterium (2H) MRS

ND Soni, A Swain, P Jacobs, H Juul… - Magnetic resonance …, 2023 - Wiley Online Library
Purpose To monitor the metabolic turnover of β‐hydroxybutyrate (BHB) oxidation using 2H‐
MRS in conjunction with intravenous administration of 2H labeled BHB. Methods Nine …

In vivo measurement of CBF using 17O NMR signal of metabolically produced H217O as a perfusion tracer

XH Zhu, Y Zhang, HM Wiesner… - Magnetic resonance …, 2013 - Wiley Online Library
The cerebral metabolic rate of oxygen of small animals can be reliably imaged using the in
vivo 17O magnetic resonance approach at high field. However, a separate measurement is …

In vivo X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging

XH Zhu, W Chen - Frontiers in aging neuroscience, 2018 - frontiersin.org
Brain relies on glucose and oxygen metabolisms to generate biochemical energy in the form
of adenosine triphosphate (ATP) for supporting electrophysiological activities and neural …