The nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's
adaptive defense mechanism against toxic substances including foreign chemicals …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

The major metabolic pathway for elimination of cholesterol is via conversion to bile acids. In
addition to this metabolic function, bile acids also act as signaling molecules that negatively …

An important requirement for physiologic homeostasis is the detoxification and removal of
endogenous hormones and xenobiotic compounds with biological activity. Much of the …

Estrogens exert a wide variety of effects on growth, development, and differentiation,
including important regulatory functions within the reproductive systems of both females and …

Vitamin K 2 is a critical nutrient required for blood clotting that also plays an important role in
bone formation. Vitamin K 2 supplementation up-regulates the expression of bone markers …

The handedness of visceral organs is conserved among vertebrates and is regulated by
asymmetric signals relayed by molecules such as Shh, Nodal and activin. The gene Pitx2 is …

The NR1I subfamily of nuclear receptors contains a phylogenetically diverse array of
receptors related to the mammalian pregnane X receptor (PXR)(NR1I2) and constitutive …

Gene inactivation is an important tool for correlation of phenotypic and genomic data,
allowing researchers to infer normal gene function based on the phenotype when the gene …

The crystal structure of the ligand binding domain (LBD) of the estrogen-related receptor 3
(ERR3) complexed with a steroid receptor coactivator-1 (SRC-1) peptide reveals a …