In 2012, we published guidelines summarizing and evaluating late 2011 evidence for
diagnosis and therapy of urea cycle disorders (UCDs). With 1: 35 000 estimated incidence …

Liver transplantation is the accepted treatment for patients with acute liver failure and liver-
based metabolic disorders. However, donor organ shortage and lifelong need for …

Hepatocyte transplantation has shown potential as an additional treatment modality for
certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute …

The conception (1) and animal modeling (2) of hepatocyte transplantation along with a
partial listing of human hepatocyte infusions over the last 13 years have been detailed in …

In rat liver epithelial cells constitutively expressing transforming growth factor α (TGFα), c-
Met is constitutively phosphorylated in the absence of its ligand, hepatocyte growth factor …

Liver failure is the cause of death for over 30,000 patients each year in the United States
alone. When this process occurs in healthy individuals with normal livers, it is termed acute …

The treatment of end-stage liver disease and acute liver failure remains a clinically relevant
issue. Although orthotopic liver transplantation is a well-established procedure, whole-organ …

In the last two decades, regenerative medicine has shown the potential for “bench‐to‐
bedside” translational research in specific clinical settings. Progress made in cell and stem …

In recent years the interest in liver cell therapy has been increasing continuously, since the
demand for whole liver transplantations in human beings far outweighs the supply. From the …

Hepatocyte transplantation is being investigated as an alternative to orthotopic liver
transplantation in patients with liver-based metabolic disorders. The progress made in this …