Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

SH Nam, J Park, H Koo - Archives of Pharmacal Research, 2023 - Springer
Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …

Challenge to overcome current limitations of cell-penetrating peptides

GC Kim, DH Cheon, Y Lee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2021 - Elsevier
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases

Q Huang, Y Chen, W Zhang, X Xia, H Li, M Qin… - Journal of Controlled …, 2024 - Elsevier
Despite the increasing global incidence of brain disorders, achieving sufficient delivery
towards the central nervous system (CNS) remains a formidable challenge in terms of …

In Vitro and In Vivo Comparison of Curcumin-Encapsulated Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles and Curcumin/Hydroxypropyl-β …

L Zhang, S Yang, LR Wong, H Xie… - Molecular …, 2020 - ACS Publications
Curcumin (CUR) has antioxidant and anti-inflammatory effects that are beneficial to
Alzheimer's disease (AD). However, the poor solubility and high instability of CUR …

Status update in the use of cell-penetrating peptides for the delivery of macromolecular therapeutics

K Kurrikoff, B Vunk, Ü Langel - Expert Opinion on Biological …, 2021 - Taylor & Francis
Introduction In this review, recent developments and applications with cell-penetrating
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

ZG Lu, J Shen, J Yang, JW Wang, RC Zhao… - … and Targeted Therapy, 2023 - nature.com
Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

A review on recent advances in amino acid and peptide-based fluorescence and its potential applications

Y Xiong, C Shi, L Li, Y Tang, X Zhang, S Liao… - New Journal of …, 2021 - pubs.rsc.org
Fluorescence is widely used to detect functional groups and ions, and peptides are used in
various fields due to their excellent biological activity. In recent years, research on …

Advanced particulate carrier-mediated technologies for nasal drug delivery

VP Chavda, G Jogi, N Shah, MN Athalye… - Journal of Drug Delivery …, 2022 - Elsevier
Nasal drug delivery has been employed as an alternate and convenient route for the
systemic availability of pharmaceuticals, particularly for potent therapeutics. This is owing to …

Designing formulation strategies for enhanced stability of therapeutic peptides in aqueous solutions: A review

PP Nugrahadi, WLJ Hinrichs, HW Frijlink, C Schöneich… - Pharmaceutics, 2023 - mdpi.com
Over the past few decades, there has been a tremendous increase in the utilization of
therapeutic peptides. Therapeutic peptides are usually administered via the parenteral …

Functional peptide-based drug delivery systems

Z Lian, T Ji - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Peptides are one of the most important functional motifs for constructing smart drug delivery
systems (DDSs). Functional peptides can be conjugated with drugs or carriers via covalent …