Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, has
traditionally been classified into embryonal rhabdomyosarcoma (ERMS) and alveolar …

Rhabdomyosarcomas are malignancies associated with a rhabdomyoblastic phenotype
which can be demonstrated morphologically or by immunohistochemistry for MYOD1 and …

Rhabdomyosarcoma (RMS) is a common childhood cancer that shares features with
developing skeletal muscle. Yet, the conservation of cellular hierarchy with human muscle …

Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of
developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes …

Research into basic developmental biology has frequently yielded insights into cancer
biology. This is particularly true for the Hedgehog (HH) pathway. Activating mutations in the …

Intratumoral hypoxia and expression of hypoxia-inducible factor-1α (HIF-1α) correlate with
metastasis and poor survival in patients with sarcoma. We show here that hypoxia controls …

Rhabdomyosarcoma (RMS), a malignant tumor of mesenchymal origin, is the third most
common extracranial malignant solid tumor in children and adolescents. However, in adults …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here
we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In …

Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of
one billion people worldwide. These individuals are at higher risk for cancer, stroke …