Grappling with (re)-emerging infectious zoonoses: Risk assessment, mitigation framework, and future directions

W Gwenzi, EC Skirmuntt, T Musvuugwa, C Teta… - International Journal of …, 2022 - Elsevier
Low-income countries (LICs) in Africa, southeast Asia, Latin America, and the Caribbeans
constitute potential hotspots for future outbreaks of infectious zoonoses. A comprehensive …

Basic aspects and epidemiological studies on leptospirosis carried out in animals in Chile: A bibliographic review

L Azócar-Aedo - Tropical Medicine and Infectious Disease, 2023 - mdpi.com
Leptospirosis is an important zoonosis worldwide. This disease affects numerous animal
species, some of them are classified as “maintenance hosts”, and others are categorized as …

Diverse lineages of pathogenic Leptospira species are widespread in the environment in Puerto Rico, USA

NE Stone, CM Hall, M Ortiz, SM Hutton… - PLOS Neglected …, 2022 - journals.plos.org
Background Leptospirosis, caused by Leptospira bacteria, is a common zoonosis
worldwide, especially in the tropics. Reservoir species and risk factors have been identified …

Concurrent colonization of rodent kidneys with multiple species and serogroups of pathogenic Leptospira

C Hamond, K LeCount, AS Browne… - Applied and …, 2023 - Am Soc Microbiol
Rodents are important reservoir hosts of pathogenic leptospires in the US Virgin Islands. Our
previous work determined that trapped rodents were colonized with Leptospira …

[HTML][HTML] A systematic review on leptospirosis in cattle: A European perspective

C Sohm, J Steiner, J Jöbstl, T Wittek, C Firth… - One Health, 2023 - Elsevier
Leptospirosis is a zoonotic disease which is globally distributed and represents a classic
One Health issue that demands a comprehensive understanding of the hosts, transmission …

Genetic manipulation of pathogenic Leptospira: CRISPR interference (CRISPRi)-mediated gene silencing and rapid mutant recovery at 37 °C

LGV Fernandes, RL Hornsby, ALTO Nascimento… - Scientific reports, 2021 - nature.com
Leptospirosis is a neglected, widespread zoonosis caused by pathogenic species of the
genus Leptospira, and is responsible for 60,000 deaths per year. Pathogenic mechanisms of …

Disease occurrence in-and the transferal of zoonotic agents by North American feedlot cattle

OY Koyun, I Balta, N Corcionivoschi, TR Callaway - Foods, 2023 - mdpi.com
North America is a large producer of beef and contains approximately 12% of the world's
cattle inventory. Feedlots are an integral part of modern cattle production in North America …

Evaluation of LipL32 and LigA/LigB Knockdown Mutants in Leptospira interrogans Serovar Copenhageni: Impacts to Proteome and Virulence

LGV Fernandes, EJ Putz, J Stasko, JD Lippolis… - Frontiers in …, 2022 - frontiersin.org
Leptospirosis is a worldwide zoonosis caused by pathogenic species of the genus
Leptospira. The recent application of CRISPR interference (CRISPRi) to Leptospira …

Immunoinformatics-Based Designing of a Multi-Epitope Chimeric Vaccine From Multi-Domain Outer Surface Antigens of Leptospira

P Kumar, S Lata, UN Shankar, M Akif - Frontiers in Immunology, 2021 - frontiersin.org
Accurate information on antigenic epitopes within a multi-domain antigen would provide
insights into vaccine design and immunotherapy. The multi-domain outer surface Leptospira …

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira

LGV Fernandes, C Hamond, BW Tibbs-Cortes, EJ Putz… - Mbio, 2024 - journals.asm.org
Leptospirosis, caused by pathogenic bacteria from the genus Leptospira, is a global
zoonosis responsible for more than one million human cases and 60,000 deaths annually …