Recent developments regarding the use of thieno [2, 3-d] pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties

K Bozorov, JY Zhao, B Elmuradov, A Pataer… - European Journal of …, 2015 - Elsevier
It is generally understood that the antitumor properties of synthetic heterocyclic compounds
are among the most powerful properties that can be made use in medicinal chemistry. More …

[HTML][HTML] Novel pyrazolo [3, 4-d] pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action

Z Ruzi, K Bozorov, L Nie, J Zhao, HA Aisa - Biomedicine & …, 2022 - Elsevier
Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition,
and mechanisms of action - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Chemistry of 2-amino-3-carbethoxythiophene and related compounds

A El-Mekabaty - Synthetic Communications, 2014 - Taylor & Francis
Full article: Chemistry of 2-Amino-3-carbethoxythiophene and Related Compounds Skip to
Main Content Taylor and Francis Online homepage Taylor and Francis Online homepage …

2‐substituted tricyclic oxazolo[5,4‐d]pyrimidine library: Design, synthesis, and cytotoxicity activity

Y Zeng, L Nie, K Bozorov, Z Ruzi… - Journal of …, 2022 - Wiley Online Library
We report the design, synthetic route, and cytotoxicity of a library of 49 newly synthesized
tricyclic oxazolo [5, 4‐d] pyrimidines. The condensed pyrimidinones were constructed from …

Furo[2,3‐d]pyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study

B Song, L Nie, K Bozorov, C Niu… - Chemistry & …, 2023 - Wiley Online Library
The chemical transformation of the tricyclic furo [2, 3‐d] pyrimidines was performed under
isosteric and scaffold‐hopping strategies focusing on the synthesis of its arylidene and imine …

Parallel synthesis of condensed pyrimidine-thiones and their antitumor activities

B Song, L Nie, K Bozorov, R Kuryazov, HA Aisa… - Research on Chemical …, 2023 - Springer
Herein, we studied the formation of thiones via C= O group conversion into the C= S
functional group-based tricyclic pyrimidinone systems using Lawesson's reagent and …

Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6, 7, 8, 9-tetrahydropyrazolo [3, 4-d] pyrido [1, 2-a] pyrimidin-4 (1H)-one as DDR2 kinase inhibitor: Synthesis …

Z Ruzi, K Bozorov, L Nie, J Zhao, HA Aisa - Bioorganic Chemistry, 2023 - Elsevier
We report the synthesis, molecular docking and anticancer properties of the novel
compound (E)-1-methyl-9-(3-methylbenzylidene)-6, 7, 8, 9-tetrahydropyrazolo [3, 4-d] pyrido …

Design, synthesis, and toward a side-ring optimization of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and their effect on melanin synthesis in murine B16 cells

LF Nie, K Bozorov, G Huang, J Zhao… - … , Sulfur, and Silicon …, 2018 - Taylor & Francis
Herein, we report the synthesis of 48 novel 3-sulfonylamides containing a tricyclic thieno [2,
3-d] pyrimidin-4 (3 H)-one moiety, and their influence on melanin synthesis in murine B16 …

Synthesis of Substituted Thieno[2,3‐d]pyrimidin‐4‐ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models

KA Bozorov, NZ Mamadalieva… - Journal of …, 2013 - Wiley Online Library
From 2‐amino‐3‐ethoxycarbonyl‐4, 5‐dimethyl‐,‐polymethylenethiophenes (1-4) were
synthesized 2, 3‐disubstituted thieno [2, 3‐d] dihydropyrrolo‐, tetrahydropyrido‐, and …

Thieno [2, 3-d] Pyrimidin-4-Ones. Part 3.* Electrophilic Ipso-Substitution Reactions of Methyl and Methoxycarbonyl Groups

BZ Elmuradov, KA Bozorov… - American …, 2013 - archive.submissionwrite.com
Interactions of 5, 6-dimethyl-(1), 3, 5, 6-trimethylthieno [2, 3-d] pyrimidin-4 (3H)-ones (2) and
2, 3-dimethyl-(5-7), 2-methyl-3-methoxycarbonylthieno [2, 3-d] dihydropyrrolo …