[HTML][HTML] An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2

F Yan, F Gao - Computational and structural biotechnology journal, 2021 - Elsevier
There is an urgent need to develop effective treatments for coronavirus disease 2019
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …

COVID-19 and diabetes: A comprehensive review of angiotensin converting enzyme 2, mutual effects and pharmacotherapy

L Xie, Z Zhang, Q Wang, Y Chen, D Lu… - Frontiers in …, 2021 - frontiersin.org
The potential relationship between diabetes and COVID-19 has been evaluated. However,
new knowledge is rapidly emerging. In this study, we systematically reviewed the …

Molecular docking and molecular dynamics simulations discover curcumin analogue as a plausible dual inhibitor for SARS-CoV-2

S Rampogu, G Lee, JS Park, KW Lee… - International Journal of …, 2022 - mdpi.com
Recently, the world has been witnessing a global pandemic with no effective therapeutics
yet, while cancer continues to be a major disease claiming many lives. The natural …

Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies

S Mousavi, S Zare, M Mirzaei… - Canadian Journal of …, 2022 - Wiley Online Library
Background. Since the beginning of the novel coronavirus (SARS‐CoV‐2) disease
outbreak, there has been an increasing interest in discovering potential therapeutic agents …

Repurposing of drugs for SARS-CoV-2 using inverse docking fingerprints

M Jukič, K Kores, D Janežič, U Bren - Frontiers in Chemistry, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 is a virus that belongs to
the Coronaviridae family. This group of viruses commonly causes colds but possesses a …

Developing a SARS-CoV-2 main protease binding prediction random forest model for drug repurposing for COVID-19 treatment

J Liu, L Xu, W Guo, Z Li, MKH Khan… - Experimental …, 2023 - journals.sagepub.com
The coronavirus disease 2019 (COVID-19) global pandemic resulted in millions of people
becoming infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

OM-85 Broncho-Vaxom®, a Bacterial Lysate, Reduces SARS-CoV-2 Binding Proteins on Human Bronchial Epithelial Cells

L Fang, L Zhou, M Tamm, M Roth - Biomedicines, 2021 - mdpi.com
In clinical studies, OM-85 Broncho-Vaxom®, a bacterial lysate, reduced viral respiratory tract
infection. Infection of epithelial cells by SARS-CoV-2 depends on the interaction of its spike …

Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3

H Huang, X Lei, C Zhao, Y Qin, Y Li, X Zhang… - Journal of …, 2024 - Am Soc Microbiol
Porcine deltacoronavirus (PDCoV) has caused enormous economic losses to the global pig
industry. However, the immune escape mechanism of PDCoV remains to be fully clarified …

Ligand-based quantitative structural assessments of SARS-CoV-2 3CLpro inhibitors: An analysis in light of structure-based multi-molecular modeling evidences

N Adhikari, S Banerjee, SK Baidya, B Ghosh… - Journal of Molecular …, 2022 - Elsevier
Due to COVID-19, the whole world is undergoing a devastating situation, but treatment with
no such drug candidates still has been established exclusively. In that context, 69 diverse …

Atomic-resolution experimental structural biology and molecular dynamics simulations of hyaluronan and its complexes

O Guvench - Molecules, 2022 - mdpi.com
This review summarizes the atomic-resolution structural biology of hyaluronan and its
complexes available in the Protein Data Bank, as well as published studies of atomic …