There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Circulatory Shock | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Background Although previous studies have suggested the potential advantages of albumin
administration in patients with severe sepsis, its efficacy has not been fully established …

La reanimación con fluidos es esencial para la supervivencia del paciente crítico en shock,
independientemente de la causa que lo origine. Hoy en día disponemos de diversos …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-
domain macromolecule, representing the main determinant of plasma oncotic pressure and …

The endothelial glycocalyx has a profound influence at the vascular wall on the transmission
of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic …

Background The role of fluid resuscitation in the treatment of children with shock and life-
threatening infections who live in resource-limited settings is not established. Methods We …

Importance Evidence supporting the choice of intravenous colloid vs crystalloid solutions for
management of hypovolemic shock remains unclear. Objective To test whether use of …