Importance Imaging biomarkers in Parkinson disease (PD) are increasingly important for
monitoring progression in clinical trials and also have the potential to improve clinical care …

Parkinson disease (PD) is characterized by heterogeneous motor and non-motor symptoms,
resulting from neurodegeneration involving various parts of the central nervous system …

Network analytical tools are increasingly being applied to brain imaging maps of resting
metabolic activity (PET) or blood oxygenation-dependent signals (functional MRI) to …

The discovery of glucocerebrosidase (GBA1) mutations as the greatest numerical genetic
risk factor for the development of Parkinson disease (PD) resulted in a paradigm shift within …

Variants in the glucocerebrosidase (GBA) gene are the most common genetic risk factor for
Parkinson disease (PD). These include pathogenic variants causing Gaucher disease …

Background Alterations in the GBA gene (NM_000157. 3) are the most important genetic risk
factor for Parkinson's disease (PD). Biallelic GBA mutations cause the lysosomal storage …

α-Synucleinopathies comprise a group of neurodegenerative diseases characterized by
altered accumulation of a protein called α-synuclein inside neurons and glial cells. This …

Objective The purpose of this study was to characterize a metabolic brain network
associated with X‐linked dystonia‐parkinsonism (XDP). Methods Thirty right‐handed …

Background Mutations in the GBA gene cause Gaucher's disease (GD) and constitute the
most frequent genetic risk factor for idiopathic Parkinson's disease (iPD). Nonmanifesting …

Highlights Imaging of the dopamine transporter (DAT)(in particular using 11C-or 18F-PE2I)
most reliably and precisely measures neurodegeneration of the dopaminergic system in …