The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Recent progress in cell culture and microfabrication technologies has contributed to the
development of cell‐based biosensors for the functional characterization and detection of …

This paper reports a multi-throughput multi-organ-on-a-chip system formed on a pneumatic
pressure-driven medium circulation platform with a microplate-sized format as a novel type …

In their normal in vivo matrix milieu, tissues assume complex well-organized three-
dimensional architectures. Therefore, the primary aim in the tissue engineering design …

Traditional cell culture and animal models utilized for preclinical drug screening have led to
high attrition rates of drug candidates in clinical trials due to their low predictive power for …

A novel targeted application of tissue engineering is the development of an in vitro
pharmacokinetic model for drug screening and toxicology. An in vitro pharmacokinetic …

ABSTRACT A multi‐organ‐on‐a‐chip (MOC), also known as a human‐on‐a‐chip, aims to
simulate whole body response to drugs by connecting microscale cell cultures of multiple …

Recent advances in integrating microengineering and tissue engineering have generated
promising microengineered physiological models for experimental medicine and …

Some organ-on-a-chip (OoC) systems for drug evaluation show better predictive capabilities
than planar, static cell cultures and animal models. One of the ongoing initiatives led by OoC …

Assay systems using in vitro cultured cells are increasingly applied for evaluation of the
efficacy, safety, and toxicity of drug candidates. In vitro cell-based assays have two main …