Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

A general principle in all cells in the body is that an essential metal–here copper–is taken up
at the plasma membrane, directed through cellular compartments for use in specific …

Abstract The P 1B-ATPases are integral membrane proteins that couple ATP hydrolysis to
metal cation transport. Widely distributed across all domains of life, these enzymes have …

Zinc is an essential micronutrient for all living organisms. It is required for signalling and
proper functioning of a range of proteins involved in, for example, DNA binding and …

Heavy metals in cells are typically regulated by PIB-type ATPases. The first structure of the
class, a Cu+-ATPase from Legionella pneumophila (LpCopA), outlined a copper transport …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Metallochaperones traffic copper (Cu+) from its point of entry at the plasma membrane to its
destination. In plants, one destination is the chloroplast, which houses plastocyanin, a Cu …

Menkes disease (MD) is caused by mutations in ATP7A, encoding a copper-transporting P-
type ATPase which exhibits copper-dependent trafficking. ATP7A is found in the Trans-Golgi …

Copper and zinc are micronutrients essential for the function of many enzymes while also
being toxic at elevated concentrations. Cu (I)-and Zn (II)-transporting P-type ATPases of …

Copper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis.
Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly …