A proposal for a serology-based approach to membranous nephropathy

AS De Vriese, RJ Glassock, KA Nath… - Journal of the …, 2017 - journals.lww.com
Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by
autoantibodies against the recently discovered podocyte antigens: the M-type …

Pathophysiological advances in membranous nephropathy: time for a shift in patient's care

P Ronco, H Debiec - The Lancet, 2015 - thelancet.com
Membranous nephropathy is a major cause of nephrotic syndrome of non-diabetic origin in
adults. It is the second or third leading cause of end-stage renal disease in patients with …

Rituximab in treatment-resistant CIDP with antibodies against paranodal proteins

L Querol, R Rojas-García, J Diaz-Manera… - Neuroimmunology & …, 2015 - AAN Enterprises
Objective: To describe the response to rituximab in patients with treatment-resistant chronic
inflammatory demyelinating polyneuropathy (CIDP) with antibodies against paranodal …

Epitope spreading of autoantibody response to PLA2R associates with poor prognosis in membranous nephropathy

B Seitz-Polski, G Dolla, C Payré… - Journal of the …, 2016 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic
membranous nephropathy. However, the value of anti-PLA2R1 antibody titers in predicting …

Association of anti-PLA2R antibodies with outcomes after immunosuppressive therapy in idiopathic membranous nephropathy

AP Bech, JM Hofstra, PE Brenchley… - Clinical Journal of the …, 2014 - journals.lww.com
Background The optimal timing and duration of immunosuppressive therapy for idiopathic
membranous nephropathy (iMN) have been debated. This study aimed to evaluate whether …

Treatment of membranous nephropathy: time for a paradigm shift

P Ruggenenti, FC Fervenza, G Remuzzi - Nature Reviews Nephrology, 2017 - nature.com
In patients with membranous nephropathy, alkylating agents (cyclophosphamide or
chlorambucil) alone or in combination with steroids achieve remission of nephrotic …

The role of complement in membranous nephropathy

H Ma, DG Sandor, LH Beck Jr - Seminars in nephrology, 2013 - Elsevier
Membranous nephropathy (MN) describes a histopathologic pattern of injury marked by
glomerular subepithelial immune deposits and collectively represents one of the most …

Membranous nephropathy: a journey from bench to bedside

JM Francis, LH Beck Jr, DJ Salant - American Journal of Kidney Diseases, 2016 - Elsevier
Lessons from an animal model that faithfully resembles human membranous nephropathy
(MN) have informed our understanding of the pathogenesis of this organ-specific …

Membranous nephropathy: from models to man

LH Beck, DJ Salant - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively
common cause of nephrotic syndrome in adults, were considered idiopathic. We now …

The diagnosis accuracy of PLA2R-AB in the diagnosis of idiopathic membranous nephropathy: a meta-analysis

Y Du, J Li, F He, Y Lv, W Liu, P Wu, J Huang, S Wei… - PloS one, 2014 - journals.plos.org
Background The presence of antibodies against the M-type phospholipase A2 receptor
(PLA2R-AB) is considered to be a promising serological diagnostic biomarker of idiopathic …