Research advances on the interactions between rabies virus structural proteins and host target cells: Accrued knowledge from the application of reverse genetics …
J Yin, X Wang, R Mao, Z Zhang, X Gao, Y Luo, Y Sun… - Viruses, 2021 - mdpi.com
Rabies is a lethal zoonotic disease caused by lyssaviruses, such as rabies virus (RABV),
that results in nearly 100% mortality once clinical symptoms appear. There are no curable …
that results in nearly 100% mortality once clinical symptoms appear. There are no curable …
A bias of Asparagine to Lysine mutations in SARS-CoV-2 outside the receptor binding domain affects protein flexibility
Introduction COVID-19 pandemic has been threatening public health and economic
development worldwide for over two years. Compared with the original SARS-CoV-2 strain …
development worldwide for over two years. Compared with the original SARS-CoV-2 strain …
IRF2 cooperates with phosphoprotein of spring viremia of carp virus to suppress antiviral response in zebrafish
W Huang, X Zhao, N Ji, J Guo, J Feng, K Chen… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT IFN regulatory factor (IRF) 2 belongs to the IRF1 subfamily, and its functions are
not yet fully understood. In this study, we showed that IRF2a was a negative regulator of the …
not yet fully understood. In this study, we showed that IRF2a was a negative regulator of the …
The Amino Acid at Position 95 in the Matrix Protein of Rabies Virus Is Involved in Antiviral Stress Granule Formation in Infected Cells
Stress granules (SGs) are dynamic structures that store cytosolic messenger
ribonucleoproteins. SGs have recently been shown to serve as a platform for activating …
ribonucleoproteins. SGs have recently been shown to serve as a platform for activating …
Molecular basis of functional effects of phosphorylation of the C-terminal domain of the rabies virus P protein
J Zhan, E Watts, AM Brice, RD Metcalfe… - Journal of …, 2022 - Am Soc Microbiol
The rabies virus (RABV) phosphoprotein (P protein) is expressed as several isoforms, which
differ in nucleocytoplasmic localization and microtubule (MT) association, mediated by …
differ in nucleocytoplasmic localization and microtubule (MT) association, mediated by …
Engineering G protein‐coupled receptors for stabilization
G protein‐coupled receptors (GPCRs) are one of the most important families of targets for
drug discovery. One of the limiting steps in the study of GPCRs has been their stability, with …
drug discovery. One of the limiting steps in the study of GPCRs has been their stability, with …
[HTML][HTML] Analysis of mechanisms of the rabies virus P protein-nucleocapsid interaction using engineered N-protein peptides and potential applications in antivirals …
J Zhan, S Chakraborty, A Sethi, YF Mok, F Yan… - Antiviral Research, 2025 - Elsevier
The Phosphoprotein (P protein) of the rabies virus has multiple roles in virus replication. A
critical function is to act as a cofactor in genome replication and mRNA production through …
critical function is to act as a cofactor in genome replication and mRNA production through …
Implication of the nuclear trafficking of rabies virus P3 protein in viral pathogenicity
AM Brice, E Watts, B Hirst, DA Jans, N Ito, GW Moseley - Traffic, 2021 - Wiley Online Library
Although the majority of viruses of the family Mononegvirales replicate exclusively in the
host cell cytoplasm, many of these viruses encode proteins that traffic between the nucleus …
host cell cytoplasm, many of these viruses encode proteins that traffic between the nucleus …
Deactivation of the antiviral state by rabies virus through targeting and accumulation of persistently phosphorylated STAT1
G Manokaran, MD Audsley, H Funakoda… - PLoS …, 2022 - journals.plos.org
Antagonism of the interferon (IFN)-mediated antiviral state is critical to infection by rabies
virus (RABV) and other viruses, and involves interference in the IFN induction and signaling …
virus (RABV) and other viruses, and involves interference in the IFN induction and signaling …
Substitution of S179P in the Lyssavirus Phosphoprotein Impairs Its Interferon Antagonistic Function
Z Wang, Y Yuan, Y Zhang, C Zhang, B Sui… - Journal of …, 2022 - Am Soc Microbiol
Lyssaviruses cause rabies, which is an acute neurological disease responsible for more
than 59,000 human deaths annually and has no available effective treatments. The …
than 59,000 human deaths annually and has no available effective treatments. The …