Molecular mechanisms of tumor resistance to radiotherapy

Y Wu, Y Song, R Wang, T Wang - Molecular Cancer, 2023 - Springer
Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Radiation‐induced normal tissue damage: oxidative stress and epigenetic mechanisms

J Wei, B Wang, H Wang, L Meng… - Oxidative medicine …, 2019 - Wiley Online Library
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it
may cause damage to healthy tissue, with both short‐term and long‐term side effects …

Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization

B Farhood, NH Goradel, K Mortezaee… - Clinical and …, 2019 - Springer
It is estimated that more than half of cancer patients undergo radiotherapy during the course
of their treatment. Despite its beneficial therapeutic effects on tumor cells, exposure to high …

Nuclear and radiological emergencies: biological effects, countermeasures and biodosimetry

E Obrador, R Salvador-Palmer, JI Villaescusa… - Antioxidants, 2022 - mdpi.com
Atomic and radiological crises can be caused by accidents, military activities, terrorist
assaults involving atomic installations, the explosion of nuclear devices, or the utilization of …

Radiation-induced inflammation and autoimmune diseases

R Yahyapour, P Amini, S Rezapour, M Cheki… - Military Medical …, 2018 - Springer
Currently, ionizing radiation (IR) plays a key role in the agricultural and medical industry,
while accidental exposure resulting from leakage of radioactive sources or radiological …

Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications

M Najafi, E Motevaseli, A Shirazi, G Geraily… - … journal of radiation …, 2018 - Taylor & Francis
Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Ionizing radiation and human health: Reviewing models of exposure and mechanisms of cellular damage. An epigenetic perspective

E Burgio, P Piscitelli, L Migliore - International journal of environmental …, 2018 - mdpi.com
We reviewed available evidence in medical literature concerning experimental models of
exposure to ionizing radiations (IR) and their mechanisms of producing damages on living …

Gender differences in oxidative stress in relation to cancer susceptibility and survival

A Allegra, S Caserta, S Genovese, G Pioggia… - Antioxidants, 2023 - mdpi.com
Genetic, developmental, biochemical, and environmental variables interact intricately to
produce sex differences. The significance of sex differences in cancer susceptibility is being …

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

M Ashrafizadeh, S Tavakol, Z Ahmadi… - Phytotherapy …, 2020 - Wiley Online Library
Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and
autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial …

Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics

R Yahyapour, E Motevaseli, A Rezaeyan… - Clinical and …, 2018 - Springer
Every year, millions of cancer patients undergo radiation therapy for treating and destroying
abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation …