Main drivers of (poly) phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

CE Iglesias-Aguirre, A Cortés-Martín… - Food & function, 2021 - pubs.rsc.org
Despite the high human interindividual variability in response to (poly) phenol consumption,
the cause-and-effect relationship between some dietary (poly) phenols (flavanols and olive …

The impact of ellagitannins and their metabolites through gut microbiome on the gut health and brain wellness within the gut–brain axis

R Banc, ME Rusu, L Filip, DS Popa - Foods, 2023 - mdpi.com
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods,
such as pomegranates, berries, and nuts. The consumption of ETs has often been …

[HTML][HTML] Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota

R García-Villalba, FA Tomás-Barberán… - Molecular Aspects of …, 2023 - Elsevier
Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but
extensively metabolized by the human gut microbiota to produce different urolithins (Uros) …

Gut bacteria involved in ellagic acid metabolism to yield human urolithin metabotypes revealed

CE Iglesias-Aguirre, R García-Villalba… - Journal of Agricultural …, 2023 - ACS Publications
We aimed to elucidate the gut bacteria that characterize the human urolithin metabotypes A
and B (UM-A and UM-B). We report here a new bacterium isolated from the feces of a …

The potential of flavonoids and flavonoid metabolites in the treatment of neurodegenerative pathology in disorders of cognitive decline

J Melrose - Antioxidants, 2023 - mdpi.com
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-
inflammatory, antiviral, and antibacterial cell protective profiles. They have received …

[HTML][HTML] Why is it important to understand the nature and chemistry of tannins to exploit their potential as nutraceuticals?

S Molino, MP Francino, JÁR Henares - Food research international, 2023 - Elsevier
Tannins comprise a large group of polyphenols that can differ widely in chemical
composition and molecular weight. The use of tannins dates back to antiquity, but it is only in …

Recent advances and perspectives on the health benefits of urolithin B, a bioactive natural product derived from ellagitannins

P Chen, Z Guo, F Chen, Y Wu, B Zhou - Frontiers in pharmacology, 2022 - frontiersin.org
Urolithin (Uro) B is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranates …

Health benefits of dietary polyphenols: Insight into interindividual variability in absorption and metabolism

B Zhang, Y Zhang, X Xing, S Wang - Current Opinion in Food Science, 2022 - Elsevier
Highlights•Latest studies on interindividual variability in health effects of polyphenols.•The
role of gene polymorphisms is worth further study.•Identification of microbial metabolic …

[HTML][HTML] Unveiling metabotype clustering in resveratrol, daidzein, and ellagic acid metabolism: Prevalence, associated gut microbiomes, and their distinctive microbial …

CE Iglesias-Aguirre, M Romo-Vaquero… - Food Research …, 2023 - Elsevier
The gut microbiota (GM) produces different polyphenol-derived metabolites, yielding high
interindividual variability and hampering consistent health effects. GM metabotypes …

Polyphenols: bioavailability, microbiome interactions and cellular effects on health in humans and animals

MB Scott, AK Styring, JSO McCullagh - Pathogens, 2022 - mdpi.com
Polyphenolic compounds have a variety of functions in plants including protecting them from
a range of abiotic and biotic stresses such as pathogenic infections, ionising radiation and …