TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor
suppression, p53 is also involved in many other biological and pathological processes, such …

The repression of repetitive elements is an important facet of p53's function as a guardian of
the genome. Paradoxically, we found that p53 activated by MDM2 inhibitors induced the …

Long non-coding RNAs (lncRNAs) were, once, viewed as “noise” for transcription. Recently,
many lncRNAs are functionally linked to several human disorders, including cancer. Coiled …

Epigenetic mechanisms comprising DNA methylation, histone modifications, and noncoding
RNAs affect chromatin structure and regulate gene expression. These mechanisms control …

To identify hepatocellular carcinoma (HCC)‐implicated long noncoding RNAs (lncRNAs),
we performed an integrative omics analysis by integrating mRNA and lncRNA expression …

Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation
results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression …

Long non-coding RNAs were once considered as “junk” RNA produced by aberrant DNA
transcription. They are now understood to play central roles in diverse cellular processes …

Summary p53, master transcriptional regulator of the genotoxic stress response, controls cell-
cycle arrest and apoptosis following DNA damage. Here, we identify a p53-induced lncRNA …