The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Precision medicine is medicine optimized to the genotypic and phenotypic characteristics of
an individual and, when present, his or her disease. It has a host of targets, including genes …

Pathway analysis is a set of widely used tools for research in life sciences intended to give
meaning to high-throughput biological data. The methodology of these tools settles in the …

'Omic'technologies adopt a holistic view of the molecules that make up a cell, tissue or
organism. They are aimed primarily at the universal detection of genes (genomics), mRNA …

The availability and utility of genome‐scale metabolic reconstructions have exploded since
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …

Chemical space—which encompasses all possible small organic molecules, including those
present in biological systems—is vast. So vast, in fact, that so far only a tiny fraction of it has …

Recombinant protein production is a multibillion-dollar market. The development of a new
product begins with the choice of a production host. While one single perfect host for every …

Metabolomics allows the simultaneous and relative quantification of thousands of different
metabolites within a given sample using sensitive and specific methodologies such as gas …

The ability to sequence whole genomes has taught us that our knowledge with respect to
gene function is rather limited with typically 30–40% of open reading frames having no …

The advent of functional genomics has enabled the molecular biosciences to come a long
way towards characterizing the molecular constituents of life. Yet, the challenge for biology …