About 20% of all human cancers are caused by chronic infection or chronic inflammatory
states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

[Frontiers in Bioscience 11, 1388-1413, May 1, 2006] 1388 Prostate cancer epidemiology Ann
W. Hsing 1 and Anand P. Chokkalingam Page 1 [Frontiers in Bioscience 11, 1388-1413, May 1 …

Background With continuous progress over the past few decades in understanding
diagnosis, treatment, and genetics, much has been learned about the prostate cancer …

Alternatively activated macrophages express the pattern recognition receptor scavenger
receptor A (SR-A). We demonstrated previously that coculture of macrophages with tumor …

Abstract Three genes, namely, ELAC2 (HPC2 locus) on chromosome 17p11, 2′-5′-
oligoisoadenlyate-synthetase-dependent ribonuclease L (RNASEL, HPC1 locus), and …

Hereditary breast and ovarian cancer syndrome (HBOC) represents 5–10% of all patients
with breast cancer and is associated with high-risk pathogenic alleles in BRCA1/2 genes …

Genetic susceptibility to prostate cancer has been consistently observed by a large number
of studies. Recently, several pieces of evidence obtained from epidemiological and …

BACKGROUND MSR1 has been reported to be associated with increased risk of prostate
cancer (PCa). METHODS We performed a meta‐analysis of all eight published studies to …

The MSR1 gene at 8p22 has been suggested as a candidate gene for hereditary prostate
cancer because germline variants have been found to be associated with the disease. Aside …