Highlights•The midgut of mosquito disease vectors contains a diverse microbial flora.•The
microbiota can modulate the mosquito immune response and influence vector competence …

Arthropod-borne viruses (arboviruses) pose a significant threat to global health, causing
human disease with increasing geographic range and severity. The recent availability of the …

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved
antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor …

Diseases caused by arthropod-borne viruses (arboviruses), such as Dengue, West Nile, and
Chikungunya, constitute a major global health burden and are increasing in incidence and …

Zika (ZIKV) and dengue virus (DENV) are transmitted to humans by Aedes mosquitoes.
However, the molecular interactions between the vector and ZIKV remain largely …

Viruses communicate with their hosts through interactions with proteins, lipids, and
carbohydrate moieties on the plasma membrane (PM), often resulting in viral absorption via …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Insects, like all eukaryotes, require sterols for structural and metabolic purposes. However,
insects, like all arthropods, cannot make sterols. Cholesterol is the dominant tissue sterol for …

The incidence and geographic range of dengue have increased dramatically in recent
decades. Climate change, rapid urbanization and increased global travel have facilitated the …

Background Wolbachia's ability to restrict arbovirus transmission makes it a promising tool to
combat mosquito-transmitted diseases. Wolbachia-infected Aedes aegypti are currently …