The intestinal epithelium serves as a dynamic barrier to the environment and integrates a
variety of signals, including those from metabolites, commensal microbiota, immune …

Many adult tissues and organs are maintained by resident stem cells that are activated in
response to injury but the mechanisms that regulate stem cell activity during regeneration …

Gut microbes play important roles in host physiology; however, the mechanisms underlying
their impact remain poorly characterized. Here, we demonstrate that microbes not only …

Coordination of stem cell activity with inflammatory responses is critical for regeneration and
homeostasis of barrier epithelia. The temporal sequence of cell interactions during injury …

Mutations that inhibit differentiation in stem cell lineages are a common early step in cancer
development, but precisely how a loss of differentiation initiates tumorigenesis is unclear …

In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can
renew itself rapidly in response to changing inputs from nutrition, the gut microbiota …

Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-
derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic …

The intestine acts as one of the interfaces between an organism and its external
environment. As the primary digestive organ, it is constantly exposed to a multitude of …

Organ fitness depends on appropriate maintenance of stem cell populations, and
aberrations in functional stem cell numbers are associated with malignancies and aging …

In all animals, the intestinal epithelium forms a tight barrier to the environment. The
epithelium regulates the absorption of nutrients, mounts immune responses, and prevents …