Low-dose or low-dose-rate ionizing radiation–induced bioeffects in animal models

FR Tang, WK Loke, BC Khoo - Journal of radiation research, 2017 - academic.oup.com
Animal experimental studies indicate that acute or chronic low-dose ionizing radiation
(LDIR)(≤ 100 mSv) or low-dose-rate ionizing radiation (LDRIR)(< 6 mSv/h) exposures may …

Radiation-induced bystander effects: what are they, and how relevant are they to human radiation exposures?

BJ Blyth, PJ Sykes - Radiation research, 2011 - meridian.allenpress.com
The term radiation-induced bystander effect is used to describe radiation-induced biological
changes that manifest in unirradiated cells remaining within an irradiated cell population …

The Linear No-Threshold Relationship Is Inconsistent with Radiation Biologic and Experimental Data1

M Tubiana, LE Feinendegen, C Yang, JM Kaminski - Radiology, 2009 - pubs.rsna.org
The carcinogenic risk induced by low doses of ionizing radiation is controversial. It cannot
be assessed with epidemiologic methods alone because at low doses the data are …

It is time to move beyond the linear no-threshold theory for low-dose radiation protection

JJ Cardarelli, BA Ulsh - Dose-Response, 2018 - journals.sagepub.com
The US Environmental Protection Agency (USEPA) is the primary federal agency
responsible for promulgating regulations and policies to protect people and the environment …

Review and evaluation of updated research on the health effects associated with low-dose ionising radiation

LT Dauer, AL Brooks, DG Hoel… - Radiation Protection …, 2010 - academic.oup.com
While radiation health risks at low doses have traditionally been estimated from high-dose
studies, we have reviewed recent literature and concluded that the mechanisms of action for …

The role of dose rate in radiation cancer risk: evaluating the effect of dose rate at the molecular, cellular and tissue levels using key events in critical pathways …

AL Brooks, DG Hoel, RJ Preston - International journal of radiation …, 2016 - Taylor & Francis
Purpose: This review evaluates the role of dose rate on cell and molecular responses. It
focuses on the influence of dose rate on key events in critical pathways in the development …

Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo

I Koturbash, A Boyko, R Rodriguez-Juarez… - …, 2007 - academic.oup.com
Radiation therapy is a primary treatment modality for brain tumors, yet it has been linked to
the increased incidence of secondary, post-radiation therapy cancers. These cancers are …

Low dose radiation and intercellular induction of apoptosis: potential implications for the control of oncogenesis

G Bauer - International journal of radiation biology, 2007 - Taylor & Francis
Purpose: This review is focused on the potential impact of low dose radiation effects on
intercellular induction of apoptosis and the underlying reactive-oxygen species (ROS) …

Low dose ionising radiation-induced hormesis: therapeutic implications to human health

YS Lau, MT Chew, A Alqahtani, B Jones, MA Hill… - Applied Sciences, 2021 - mdpi.com
The concept of radiation-induced hormesis, whereby a low dose is beneficial and a high
dose is detrimental, has been gaining attention in the fields of molecular biology …

The dose window for radiation-induced protective adaptive responses

REJ Mitchel - Dose-Response, 2010 - journals.sagepub.com
Adaptive responses to low doses of low LET radiation occur in all organisms thus far
examined, from single cell lower eukaryotes to mammals. These responses reduce the …