CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

Several studies have demonstrated that memory T cells including stem cell memory (Tscm)
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …

A lack of regulatory T (TReg) cells that express CD4, CD25 and forkhead box P3 (FOXP3)
results in severe autoimmunity in both mice and humans. Since the discovery of TReg cells …

Immune regulation is fundamental to any immune response to ensure that it is appropriate
for the perceived threat to the host. Following cell and organ transplantation, it is essential to …

The human major histocompatibility complex is a family of genes that encodes HLAs, which
have a crucial role in defence against foreign pathogens and immune surveillance of …

Pathogen invasion induces a rapid inflammatory response initiated through the recognition
of pathogen‐derived molecules by pattern recognition receptors (PRRs) expressed on both …

Regulatory T cells (Treg) play a dominant role in suppression of autoimmune pathology, as
rescue of Treg number and/or function in model systems can both prevent and reverse …

Defects in immune regulation have been implicated in the pathogenesis of diabetes in
mouse and in man. In vitro assays using autologous regulatory (Treg) and responder …

In the last years, mesenchymal stem cell (MSC)-based therapies have become an
interesting therapeutic opportunity for the treatment of rheumatoid arthritis (RA) due to their …

Cell therapy with autologous donor-specific regulatory T cells (Tregs) is a promising strategy
to minimize immunosuppression in transplant recipients. Chimeric antigen receptor (CAR) …