Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Mutations in the KCNA1 gene, which encodes voltage-gated Kv1. 1 potassium channel α-
subunits, cause a variety of human diseases, complicating simple genotype–phenotype …

Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the
quality of life, and associated with several comorbidities. Sleep impairment is a frequent …

Orexin is a neurotransmitter produced by a small group of hypothalamic neurons. Besides its
well-known role in the regulation of the sleep-wake cycle, the orexin system was shown to …

As a highly selective and semi-permeable barrier that separates the circulating blood from
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …

The correlation between sleep and epilepsy has been argued over the past decades among
scientists. Although the similarities and contrasts between sleep and epilepsy had been …

Sudden unexpected death in epilepsy : Current Opinion in Neurology Sudden unexpected
death in epilepsy : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …

The ketogenic diet (KD) is an effective therapy primarily used in pediatric patients whom are
refractory to current anti-seizure medications. The mechanism of the KD is not completely …

Summary Gain-of-function (GOF) variants in K+ channels cause severe childhood
epilepsies, but there are no mechanisms to explain how increased K+ currents lead to …

Lateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical
excitation. Abnormally high excitation produces epileptic seizures, which affect millions of …