Monoclonal antibodies (mAbs) have established themselves as the leading
biopharmaceutical therapeutic modality. The establishment of robust manufacturing …

Hundreds of therapeutic monoclonal antibodies (mAbs) are currently in development, and
many companies have multiple antibodies in their pipelines. Current methodology used in …

Developing therapeutic monoclonal antibodies at pandemic pace | Nature Biotechnology Skip
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The rapid development of high-yielding and robust manufacturing processes for monoclonal
antibodies is an area of significant focus in the biopharmaceutical landscape. Advances in …

This article reviews technology trends in antibody purification. Section 1 discusses non-
chromatography methods, including precipitation, liquid–liquid extraction, and high …

This paper presents a systems approach to evaluating the potential of integrated continuous
bioprocessing for monoclonal antibody (mAb) manufacture across a product's lifecycle from …

Technology development initiatives targeted for monoclonal antibody purification may be
motivated by manufacturing limitations and are often aimed at solving current and future …

Plants offer the tantalizing prospect of low-cost automated manufacturing processes for
biopharmaceutical proteins, but several challenges must be addressed before such goals …

This paper presents an integrated experimental and modelling approach to evaluate the
potential of semi-continuous chromatography for the capture of monoclonal antibodies …

Dramatic improvements in cell culture titers, product quality constraints, new regulatory
directives, and the emergence of biosimilars have necessitated the development of more …