Coronavirus infections and type 2 diabetes—shared pathways with therapeutic implications

DJ Drucker - Endocrine reviews, 2020 - academic.oup.com
Abstract Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic, and
viral infections. The severe acute respiratory syndrome (SARS)-CoV-2 (also referred to as …

Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and Pathogenesis

A Cafaro, I Schietroma, L Sernicola, R Belli… - International Journal of …, 2024 - mdpi.com
Each time the virus starts a new round of expression/replication, even under effective
antiretroviral therapy (ART), the transactivator of viral transcription Tat is one of the first HIV-1 …

Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

LL Baggio, EM Varin, JA Koehler, X Cao… - Nature …, 2020 - nature.com
Abstract Dipeptidyl peptidase-4 (DPP4) modulates inflammation by enzymatic cleavage of
immunoregulatory peptides and through its soluble form (sDPP4) that directly engages …

Effect of linagliptin plus insulin in comparison to insulin alone on metabolic control and prognosis in hospitalized patients with SARS-CoV-2 infection

R Guardado-Mendoza, MA Garcia-Magaña… - Scientific reports, 2022 - nature.com
To evaluate the effect of the combination of linagliptin and insulin on metabolic control and
prognosis in hospitalized patients with severe acute respiratory syndrome coronavirus 2 …

The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo

SR Lin, CH Chang, MJ Tsai, H Cheng… - … in Chronic Disease, 2019 - journals.sagepub.com
Dipeptidyl peptidase IV (DPP-4), an incretin glucagon-like peptide-1 (GLP-1) degrading
enzyme, contains two forms and it can exert various physiological functions particular in …

Deiminated proteins and extracellular vesicles-novel serum biomarkers in whales and orca

B Magnadóttir, P Uysal-Onganer, I Kraev… - … and Physiology Part D …, 2020 - Elsevier
Peptidylarginine deiminases (PADs) are a family of phylogenetically conserved calcium-
dependent enzymes which cause post-translational protein deimination. This can result in …

Deiminated proteins in extracellular vesicles and serum of llama (Lama glama)—Novel insights into camelid immunity

MF Criscitiello, I Kraev, S Lange - Molecular Immunology, 2020 - Elsevier
Peptidylarginine deiminases (PADs) are phylogenetically conserved calcium-dependent
enzymes which post-translationally convert arginine into citrulline in target proteins in an …

Low levels of soluble DPP4 among Saudis may have constituted a risk factor for MERS endemicity

KR Alkharsah, SA Aljaroodi, JU Rahman, AN Alnafie… - Plos one, 2022 - journals.plos.org
Most of the cases of Middle East respiratory syndrome coronavirus (MERS-CoV) were
reported in Saudi Arabia. Dipeptidyl peptidase-4 (DPP4) was identified as the receptor for …

Systemic DPP4/CD26 is associated with natural HIV-1 control: Implications for COVID-19 susceptibility

Y Govender, S Shalekoff, O Ebrahim, Z Waja… - Clinical …, 2021 - Elsevier
The current intersection of the COVID-19 and HIV-1 pandemics, has raised concerns about
the risk for poor COVID-19 outcomes particularly in regions like sub-Saharan Africa …

Non-human primate determinants of natural killer cells in tissues at steady-state and during simian immunodeficiency virus infection

N Huot, P Rascle, C Petitdemange… - Frontiers in …, 2020 - frontiersin.org
Natural killer (NK) cells play essential roles in immunity to viruses and tumors. Their function
is genetically determined but also modulated by environmental factors. The distribution and …