Functional cure of hepatitis B is defined as sustained undetectable circulating HBsAg and
HBV DNA after a finite course of treatment. Barriers to HBV cure include the reservoirs for …

Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …

Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases.
The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double …

Conclusions HBV cccDNA minichromosomes in distinct epigenetic transcriptional states
showed a similar reduction rate during cell division but significantly differed in their …

Hepatitis B virus (HBV) infection remains a global public health problem with changing
epidemiology due to several factors including vaccination policies and migration. This …

Background & Aims It has been proposed that serum hepatitis B core-related antigen
(HBcrAg) reflects intrahepatic covalently closed circular (ccc) DNA levels. However, the …

Current antiviral therapies, such as pegylated interferon-α and nucleos (t) ide analogues,
effectively improve the quality of life of patients with chronic hepatitis B. However, they can …

临床上广泛使用的一线抗HBV 药物核苷(酸) 类似物(NAs) 可有效地抑制HBV DNA 复制,
显著减缓慢性乙型肝炎(CHB) 患者的疾病进展, 减少包括肝衰竭和肝癌在内的终末期肝病的发生 …

Hepatitis B virus (HBV) infection remains a major public health concern worldwide with
about 257 million individuals chronically infected. Current therapies can effectively control …

Chronic hepatitis B virus (HBV) infection continues to be a major health burden worldwide; it
can cause various degrees of liver damage and is strongly associated with the development …