Neuroinflammation: a potential risk for dementia

MA Ahmad, O Kareem, M Khushtar, M Akbar… - International journal of …, 2022 - mdpi.com
Dementia is a neurodegenerative condition that is considered a major factor contributing to
cognitive decline that reduces independent function. Pathophysiological pathways are not …

[HTML][HTML] Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain

O Rabie, HAS El-Nashar, MY George… - Biomedicine & …, 2023 - Elsevier
Cyclophosphamide (CPA) is a chemotherapeutic drug used for various types of cancers.
However, patients receiving CPA for long periods suffer cognitive impairment associated …

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

ECD Gonçalves, GM Baldasso, MA Bicca, RS Paes… - Molecules, 2020 - mdpi.com
Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …

Neuroprotective effect of quercetin and nano-quercetin against cyclophosphamide-induced oxidative stress in the rat brain: role of Nrf2/HO-1/Keap-1 signaling …

DA AbdElrazek, MA Ibrahim, NH Hassan, EI Hassanen… - Neurotoxicology, 2023 - Elsevier
Quercetin (Qu) is a powerful flavanol antioxidant that is naturally found in plants and is part
of the flavonoid family. Qu has a wide range of biological properties, such as …

Animal models of chemotherapy-induced cognitive decline in preclinical drug development

J John, M Kinra, J Mudgal, GL Viswanatha… - …, 2021 - Springer
Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …

Nerolidol attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/MAPK signaling pathways in doxorubicin-induced acute cardiotoxicity in rats

S Arunachalam, MF Nagoor Meeran, S Azimullah… - Antioxidants, 2021 - mdpi.com
The clinical usage of doxorubicin (DOX), a potent anthracycline antineoplastic drug, is often
limited by its cardiotoxic effects. Thus, for improving usage of DOX, the aim of this study was …

Molecular mechanisms underlying cyclophosphamide-induced cognitive impairment and strategies for neuroprotection in preclinical models

KM Ibrahim, SF Darwish, EM Mantawy… - Molecular and Cellular …, 2024 - Springer
Cyclophosphamide has drastically enhanced the expectancy and quality of life of cancer
patients. However, it is accompanied by diverse neurological complications which are …

Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro …

A Yardim, C Gur, S Comakli, S Ozdemir, S Kucukler… - Neurotoxicology, 2022 - Elsevier
Bortezomib (BTZ), a proteasome inhibitor, causes dose-limiting peripheral neuropathy in
humans. Berberine (BBR), which has various biological and pharmacological properties, is …

Chemobrain in breast cancer: mechanisms, clinical manifestations, and potential interventions

GR Onzi, N D'Agustini, SC Garcia, SS Guterres… - Drug safety, 2022 - Springer
Among the potential adverse effects of breast cancer treatment, chemotherapy-related
cognitive impairment (CRCI) has gained increased attention in the past years. In this review …

[HTML][HTML] Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-κB/MAPK signalling pathways and activating the Nrf2 …

Z Ou, L Zhu, C Huang, C Ma, L Kong, X Lin… - Ecotoxicology and …, 2021 - Elsevier
Betulinic acid (BA), a pentacyclic triterpenoid, has been associated with several biological
effects, such as antioxidant, anti-inflammatory and antiviral activities. Previous studies have …