Iron chelators as a therapeutic option for Alzheimer's disease—A mini-review

OD Schreiner, TG Schreiner - Frontiers in Aging, 2023 - frontiersin.org
Neurodegenerative disorders, particularly Alzheimer's disease (AD), remain a great
challenge regarding the finding of effective treatment, one main reason being the incomplete …

Examining the Role of a Functional Deficiency of Iron in Lysosomal Storage Disorders with Translational Relevance to Alzheimer's Disease

SM LeVine - Cells, 2023 - mdpi.com
The recently presented Azalea Hypothesis for Alzheimer's disease asserts that iron
becomes sequestered, leading to a functional iron deficiency that contributes to …

R-mixup: Riemannian mixup for biological networks

X Kan, Z Li, H Cui, Y Yu, R Xu, S Yu, Z Zhang… - Proceedings of the 29th …, 2023 - dl.acm.org
Biological networks are commonly used in biomedical and healthcare domains to effectively
model the structure of complex biological systems with interactions linking biological entities …

Protective Roles of Hydrogen Sulfide in Alzheimer's Disease and Traumatic Brain Injury

BD Paul, AA Pieper - Antioxidants, 2023 - mdpi.com
The gaseous signaling molecule hydrogen sulfide (H2S) critically modulates a plethora of
physiological processes across evolutionary boundaries. These include responses to stress …

[HTML][HTML] Iron homeostasis in older adults: balancing nutritional requirements and health risks

RS Zeidan, M Martenson, JA Tamargo… - The Journal of nutrition …, 2024 - Elsevier
Iron plays a crucial role in many physiological processes, including oxygen transport,
bioenergetics, and immune function. Iron is assimilated from food and also recycled from …

The effect of Tau K677 lactylation on ferritinophagy and ferroptosis in Alzheimer's disease

X An, J He, P Xie, C Li, M Xia, D Guo, B Bi, G Wu… - Free Radical Biology …, 2024 - Elsevier
Alzheimer's disease (AD) is characterized by cognitive decline and the accumulation of
amyloid-beta plaques and hyperphosphorylated tau protein. The role of tau lactylation at the …

Exploring Potential Mechanisms Accounting for Iron Accumulation in the Central Nervous System of Patients with Alzheimer's Disease

SM LeVine - Cells, 2024 - mdpi.com
Elevated levels of iron occur in both cortical and subcortical regions of the CNS in patients
with Alzheimer's disease. This accumulation is present early in the disease process as well …

Do toenail manganese and iron levels reflect brain metal levels or brain metabolism in welders?

G Nossa, H Monsivais, CG Lee, G Francis, EM Wells… - NeuroToxicology, 2024 - Elsevier
Inhalation of welding fumes can cause metal accumulation in the brain, leading to
Parkinsonian-like symptoms. Metal accumulation and altered neurochemical profiles have …

Accelerated model‐based T1, T2* and proton density mapping using a Bayesian approach with automatic hyperparameter estimation

S Huang, JJ Lah, JW Allen, D Qiu - Magnetic Resonance in …, 2024 - Wiley Online Library
Purpose To achieve automatic hyperparameter estimation for the model‐based recovery of
quantitative MR maps from undersampled data, we propose a Bayesian formulation that …

Ferroptosis in Cognitive Impairment Associated with Diabetes and Alzheimer's Disease: Mechanistic Insights and New Therapeutic Opportunities

M Ma, G Jing, Y Tian, R Yin, M Zhang - Molecular Neurobiology, 2024 - Springer
Cognitive impairment associated with diabetes and Alzheimer's disease has become a
major health issue affecting older individuals, with morbidity rates growing acutely each …