Background The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has ravaged lives
across the globe since December 2019, and new cases are still on the rise. Peoples' …

The involvement of iron in the pathogenesis of Alzheimer's disease (AD) may be
multifaceted. Besides potentially inducing oxidative damage, the bioavailability of iron may …

Proteostatic regulation of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine
biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants …

Pharmacological chaperones are chemical compounds able to bind proteins and stabilize
them against denaturation and following degradation. Some pharmacological chaperones …

Dopa-responsive dystonia (DRD) is a rare movement disorder associated with defective
dopamine synthesis. This impairment may be due to the fact of a deficiency in GTP …

Tyrosine hydroxylase (TH) is a multi‐domain, homo‐oligomeric enzyme that catalyses the
rate‐limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of …

Tyrosine hydroxylase catalyses the hydroxylation of L-tyrosine to l-DOPA, the rate-limiting
step in the synthesis of catecholamines. Mutations in the TH gene encoding tyrosine …

Medium chain acyl-CoA dehydrogenase (MCAD) deficiency (MCADD) is associated with
ACADM gene mutations, leading to an impaired function and/or structure of MCAD …

Tyrosine hydroxylase (TH) catalyses the (6 R)-L-erythro-5, 6, 7, 8-tetrahydrobiopterin (BH4)-
dependent conversion of L-tyrosine to L-3, 4-dihydroxyphenylalanine (L-Dopa), which is the …

Compound screening in biological assays and subsequent optimization of hits is
indispensable for the development of new molecular research tools and drug candidates. To …