Lipids and lipid derivatives for RNA delivery
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Modification of lipid-based nanoparticles: An efficient delivery system for nucleic acid-based immunotherapy
Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are
considered to be one of the most efficient drug delivery platforms. Due to the prominent …
considered to be one of the most efficient drug delivery platforms. Due to the prominent …
Recent advances in nanoparticle-mediated siRNA delivery
Inhibiting specific gene expression by short interfering RNA (siRNA) offers a new therapeutic
strategy to tackle many diseases, including cancer, metabolic disorders, and viral infections …
strategy to tackle many diseases, including cancer, metabolic disorders, and viral infections …
[HTML][HTML] Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol
MT Neary, LM Mulder, PS Kowalski… - Journal of Controlled …, 2024 - Elsevier
In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …
Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy
A multifunctional gold (Au) nanorod (NR)-based nanocarrier capable of co-delivering small
interfering RNA (siRNA) against achaete-scute complex-like 1 (ASCL1) and an anticancer …
interfering RNA (siRNA) against achaete-scute complex-like 1 (ASCL1) and an anticancer …
A microfluidic method to synthesize transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia
The siRNA LOR-1284 targets the R2 subunit of ribonucleotide reductase (RRM2) and has
shown promise in cancer therapy. In this study, transferrin (Tf) conjugated lipid nanoparticles …
shown promise in cancer therapy. In this study, transferrin (Tf) conjugated lipid nanoparticles …
Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations
Many cationic lipids have been developed for lipid-based nanoparticles (LNPs) for delivery
of siRNA and microRNA (miRNA). However, less attention has been paid to “helper lipids” …
of siRNA and microRNA (miRNA). However, less attention has been paid to “helper lipids” …
Clinical translation of immunoliposomes for cancer therapy: Recent perspectives
Introduction: Liposomes have been extensively investigated as drug delivery vehicles.
Immunoliposomes (ILs) are antibody-conjugated liposomes designed to selectively target …
Immunoliposomes (ILs) are antibody-conjugated liposomes designed to selectively target …
Toxicological profile of lipid-based nanostructures: are they considered as completely safe nanocarriers?
Nanoparticles are ubiquitous in the environment and are widely used in medical science (eg
bioimaging, diagnosis, and drug therapy delivery). Due to unique physicochemical …
bioimaging, diagnosis, and drug therapy delivery). Due to unique physicochemical …
RNA therapeutics in oncology: advances, challenges, and future directions
AR MacLeod, ST Crooke - The Journal of Clinical …, 2017 - Wiley Online Library
RNA‐based therapeutic technologies represent a rapidly expanding class of therapeutic
opportunities with the power to modulate cellular biology in ways never before possible …
opportunities with the power to modulate cellular biology in ways never before possible …