Introduction: The RAS/RAF/MAP kinase–ERK kinase (MEK)/extracellular-signal-regulated
kinase (ERK)(MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR)(PI3K) …

The abundance of tumour‐infiltrating T‐cells has been associated with microsatellite
instability (MSI) and a favourable prognosis in colorectal cancer. However, numerous …

Colorectal cancer (CRC) is one of the deadliest human malignancies worldwide. Several
molecular pathways have been demonstrated to be involved in the initiation and …

Purpose PIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase
(PI3K) is mutated and/or amplified in various neoplasia, including lung cancer. Here we …

Mutations in PIK3CA are present in 10 to 15% of colorectal carcinomas. We aimed to
examine how PIK3CA mutations relate to other molecular alterations in colorectal …

Rapidly growing insights into the molecular biology of colorectal cancer (CRC) and recent
developments in gene sequencing and molecular diagnostics have led to high expectations …

Phosphoinositide kinases (PIKs) are a group of lipid kinases that are important upstream
activators of various significant signaling pathways. Hyperactivation of the PI3K/AKT/mTOR …

Colorectal cancer (CRC) is a major cause of cancer death worldwide. CRC has poor
prognosis and there is a crucial need for new diagnostic and prognostic biomarkers to avoid …

Regular use of aspirin reduces incidence and mortality of various cancers, including
colorectal cancer. Anticancer effect of aspirin represents one of the 'Provocative Questions' …

Background The phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin
(mTOR) pathway (PI3K/AKT/mTOR pathway) plays a key role in cancer. We performed this …