Allergists and clinical immunologists around the world are increasingly faced with the task of
addressing drug allergy and hypersensitivity due to the increase in drug reactions …

The phosphatidylinositol 3–kinase (PI3K) signaling pathway is involved in a broad range of
cellular processes, including growth, metabolism, differentiation, proliferation, motility, and …

Activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) is an inborn error of
immunity with clinical manifestations including infections, lymphoproliferation, autoimmunity …

Hepatocellular carcinoma (HCC) cells exploit an aberrant transcriptional program to sustain
their infinite growth and progression. Emerging evidence indicates that the continuous and …

Portal hypertension is a major contributor to decompensation and death from liver disease, a
global health problem. Here, we demonstrate homozygous damaging mutations in GIMAP5 …

Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency
(PID) in adulthood and is characterized by severe reduction of immunoglobulin serum levels …

Porto-sinusoidal vascular disorder is a rare liver disease. The pathophysiological
mechanisms underlying the development of porto-sinusoidal vascular disorder are …

Loss‐of‐function mutations in genes that encode for components of the telomere repair
complex cause accelerated telomere shortening. Hepatic involvement has been recognized …

Phosphoinositide-3-kinase δ (PI3Kδ) is found in immune cells and is part of the
PI3K/AKT/mTOR/S6K signalling pathway essential to cell survival, growth and differentiation …

Mutations in two genes can result in activated PI3Kδ syndrome (APDS), a rare
immunodeficiency disease with limited therapeutic options. Seletalisib, a potent, selective …