Fasting triggers diverse physiological adaptations including increases in circulating fatty
acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving …

The pancreas and liver arise from a common pool of progenitors. However, the underlying
mechanisms that drive their lineage diversification from the foregut endoderm are not fully …

Purpose: The abundance and biological contribution of cancer-associated fibroblasts (CAF)
in glioblastoma (GBM) are poorly understood. Here, we aim to uncover its molecular …

Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age
and tissue damage and secrete factors that promote atherosclerotic plaque vulnerability and …

Compounds binding to the bromodomains of bromodomain and extra-terminal (BET) family
proteins, particularly BRD4, are promising anticancer agents. Nevertheless, side effects and …

Mutations leading to colony‐stimulating factor‐1 receptor (CSF‐1R) loss‐of‐function or
haploinsufficiency cause CSF1R‐related leukoencephalopathy (CRL), an adult‐onset …

GpsB links peptidoglycan synthases to other proteins that determine the shape of the
respiratory pathogen Streptococcus pneumoniae (pneumococcus; Spn) and other low‐GC …

Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA
processing factors. Type I PRMT enzymes catalyze mono-and asymmetric dimethylation; …

Gut bacteria hold the potential to produce a broad range of metabolites that can modulate
human functions, including molecules with neuroactive potential. One such molecule is γ …

In development, pioneer transcription factors access silent chromatin to reveal lineage-
specific gene programs. The structured DNA-binding domains of pioneer factors have been …