Japan faces an increasing incidence of heart disease, owing to a shift towards a
westernized lifestyle and an aging demographic. In cases where conventional interventions …

Cardiac tissue has minimal endogenous regenerative capacity in response to injury.
Treatment options are limited following tissue damage after events such as myocardial …

The process by which fibroblasts are directly reprogrammed into cardiomyocytes involves
two stages; initiation and maturation. Initiation represents the initial expression of factors that …

Ischemic heart disease is a predominant cause of death worldwide. The loss or death of
cardiomyocytes due to restricted blood flow often results in a cardiac injury. Myofibroblasts …