Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

EM Hol, M Pekny - Current opinion in cell biology, 2015 - Elsevier
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system …

GFAP in health and disease

J Middeldorp, EM Hol - Progress in neurobiology, 2011 - Elsevier
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche

P Codega, V Silva-Vargas, A Paul… - Neuron, 2014 - cell.com
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

Human adult neurogenesis across the ages: an immunohistochemical study

CV Dennis, LS Suh, ML Rodriguez… - Neuropathology and …, 2016 - Wiley Online Library
Aims Neurogenesis in the postnatal human brain occurs in two neurogenic niches; the
subventricular zone (SVZ) in the wall of the lateral ventricles and the subgranular zone …

Astrogliosis: an integral player in the pathogenesis of Alzheimer's disease

LM Osborn, W Kamphuis, WJ Wadman, EM Hol - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene …

HF North, C Weissleder, JM Fullerton, R Sager… - Translational …, 2021 - nature.com
Inflammation regulates neurogenesis, and the brains of patients with schizophrenia and
bipolar disorder have reduced expression of neurogenesis markers in the subependymal …

GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease

W Kamphuis, C Mamber, M Moeton, L Kooijman… - 2012 - journals.plos.org
Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP
splice isoforms show differential expression patterns in the human brain. GFAPδ is …

A mosaic world: puzzles revealed by adult neural stem cell heterogeneity

Z Chaker, P Codega, F Doetsch - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain. The
ventricular–subventricular zone (V‐SVZ), adjacent to the lateral ventricles, gives rise to …

Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults

S Cipriani, I Ferrer, E Aronica, GG Kovacs… - Cerebral …, 2018 - academic.oup.com
Neuropathological conditions might affect adult granulogenesis in the adult human dentate
gyrus. However, radial glial cells (RGCs) have not been well characterized during human …