Chromatin reader domains are protein folds that bind to post-translational modifications of
histones and other chromatin-associated proteins. Compared to other families of reader …

The tricarboxylic acid cycle, nutrient oxidation, histone acetylation and synthesis of lipids,
glycans and haem all require the cofactor coenzyme A (CoA). Although the sources and …

Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in
multiple biological processes. However, the regulatory mechanism and functional …

Adenoviral E1A binding protein 300 kDa (p300) and its closely related paralog CREB
binding protein (CBP) are promising therapeutic targets for human cancer. Here, we report …

Metabolism has been implicated in cell fate determination, particularly through epigenetic
modifications. Similarly, lipid remodeling also plays a role in regulating cell fate. Here, we …

Intricate coupling between metabolism and protein post-translational modifications (PTMs)
has emerged as a fundamental aspect of cellular regulation. Recent studies demonstrate …

The transcriptional coactivators EP300 and CREBBP are critical regulators of gene
expression that share high sequence identity but exhibit nonredundant functions in basal …

The human acetyltransferase paralogues EP300 and CREBBP are master regulators of
lysine acetylation whose activity has been implicated in various cancers. In the half-decade …

Metabolism is typically contextualized in conjunction with proliferation and growth. The roles
of metabolic enzymes beyond metabolism—such as in innate immune responses—are …

Acquired resistance to chemotherapy is one of the major causes of mortality in advanced
nasopharyngeal carcinoma (NPC). However, effective strategies are limited and the …