The growth and development of cancer are directly correlated to the suppression of the
immune system. A major breakthrough in cancer immunotherapy depends on various …

Immunotherapy is a new pillar of cancer therapy that provides novel opportunities to treat
solid tumors. In this context, the development of new drugs targeting immune checkpoints is …

Immune checkpoint inhibitors (ICIs) show prominent clinical activity across multiple
advanced tumors. However, less than half of patients respond even after molecule-based …

Abstract Hematopoietic progenitor kinase 1 (HPK1), a 97-kDa serine/threonine Ste20-
related protein kinase, is a negative regulator of T cells, B cells, and dendritic cells-mediated …

Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the
main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV …

Vulvar cancer (VC) is a rare neoplasm, usually arising in postmenopausal women, although
human papilloma virus (HPV)-associated VC usually develop in younger women …

Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular
components and has a crucial role in the pathogenesis and drug resistance of various …

Background N6-methyladenosine (m6A) and 5-methylcytosine (m5C) can modify long non-
coding RNAs (lncRNAs), thereby affecting tumorigenesis and tumor progression. However …

Immunotherapy has revolutionized cancer treatment and brought new aspects into tumor
immunology. Effective immunotherapy will require using the suitable target antigens …

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second
leading cause of cancer death, which accounts for approximately 10% of all new cancer …