[PDF][PDF] Parkinson disease epidemiology, pathology, genetics, and pathophysiology

DK Simon, CM Tanner, P Brundin - Clinics in geriatric medicine, 2020 - Elsevier
SYNOPSIS (1 paragraph): Parkinson's disease (PD) is a complex age-related
neurodegenerative disease associated with dopamine deficiency and both motor and …

The epidemiology of Parkinson's disease: risk factors and prevention

A Ascherio, MA Schwarzschild - The Lancet Neurology, 2016 - thelancet.com
Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …

Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Parkinson's disease

LV Kalia, AE Lang - The Lancet, 2015 - thelancet.com
Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long
been characterised by the classical motor features of parkinsonism associated with Lewy …

LRRK2 and idiopathic Parkinson's disease

EM Rocha, MT Keeney, R Di Maio… - Trends in …, 2022 - cell.com
The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …

Preventing Parkinson's disease: an environmental agenda

BR De Miranda, SM Goldman… - Journal of …, 2022 - content.iospress.com
Fueled by aging populations and continued environmental contamination, the global burden
of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases …

Epidemiology of Parkinson's disease

A Elbaz, L Carcaillon, S Kab, F Moisan - Revue neurologique, 2016 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's. PD is considered a multifactorial disorder that results, in most cases, from the …

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

M Chin-Chan, J Navarro-Yepes… - Frontiers in cellular …, 2015 - frontiersin.org
Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease

M Tsalenchuk, SM Gentleman, SJ Marzi - npj Parkinson's Disease, 2023 - nature.com
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

Six action steps to address global disparities in Parkinson disease: a World Health Organization priority

N Schiess, R Cataldi, MS Okun… - JAMA …, 2022 - jamanetwork.com
Importance The Global Burden of Disease study conducted between 1990 and 2016, based
on a global study of 195 countries and territories, identified Parkinson disease (PD) as the …