Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins,
various functions, and unique lipid and protein compositions have been introduced as …

Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative
disorder characterized by progressive cognitive dysfunction. Epidemiological investigation …

The brain contains the highest concentration of cholesterol in the human body, which
emphasizes the importance of cholesterol in brain physiology. Cholesterol is involved in …

The intrinsically disordered protein tau aggregates into β-sheet amyloid fibrils that spread in
human brains afflicted with Alzheimer's disease and other neurodegenerative diseases. Tau …

Previous studies show that 3β-hydroxysterol-Δ24 reductase (DHCR24) has a remarked
decline in the brain of AD patients. In brain cholesterol synthetic metabolism, DHCR24 is …

Alzheimer's disease (AD) diagnosis is based on invasive and expensive biomarkers.
Regarding AD pathophysiological mechanisms, there is evidence of a link between AD and …

Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia and
one of the top medical concerns worldwide. Currently, the approved drugs to treat AD are …

Background Brain inflammation contributes significantly to the pathophysiology of
Alzheimer's disease, and it is manifested by glial cell activation, increased production of …