Microbial cell factories for the production of flavonoids–barriers and opportunities

H Li, Y Lyv, S Zhou, S Yu, J Zhou - Bioresource Technology, 2022 - Elsevier
Flavonoids are natural plant products with important nutritional value, health-promoting
benefits, and therapeutic potential. The use of microbial cell factories to generate flavonoids …

Cellular Adaptations to Cytoplasmic Mg2+ Limitation

EA Groisman, C Chan - Annual review of microbiology, 2021 - annualreviews.org
Mg2+ is the most abundant divalent cation in living cells. It is essential for charge
neutralization, macromolecule stabilization, and the assembly and activity of ribosomes and …

Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis

XR Jiang, X Yan, LP Yu, XY Liu, GQ Chen - Nature communications, 2021 - nature.com
Hydroxypropionic acid (3HP), an important three carbon (C3) chemical, is designated as
one of the top platform chemicals with an urgent need for improved industrial production …

[HTML][HTML] Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A–dependent bioproduction in rewired Pseudomonas putida

E Kozaeva, S Volkova, MRA Matos, MP Mezzina… - Metabolic …, 2021 - Elsevier
Pseudomonas putida is evolutionarily endowed with features relevant for bioproduction,
especially under harsh operating conditions. The rich metabolic versatility of this species …

Nutrient-limited operational strategies for the microbial production of biochemicals

H Rajpurohit, MA Eiteman - Microorganisms, 2022 - mdpi.com
Limiting an essential nutrient has a profound impact on microbial growth. The notion of
growth under limited conditions was first described using simple Monod kinetics proposed in …

Improve the Biosynthesis of Baicalein and Scutellarein via Manufacturing Self-Assembly Enzyme Reactor In Vivo

D Ji, J Li, F Xu, Y Ren, Y Wang - ACS Synthetic Biology, 2021 - ACS Publications
Baicalein and scutellarein are bioactive flavonoids isolated from the traditional Chinese
medicine Scutellaria baicalensis Georgi; however, there is a lack of effective strategies for …

Optimization studies about efficient biobutanol production from industrial tea waste by Clostridium beijerinckii

N Tekin, SE Karatay, G Dönmez - Fuel, 2023 - Elsevier
The current study aims to evaluate industrial tea waste (ITW), which generated massive
quantities annually, on biobutanol production by Clostridium beijerinckii. Some critical …

Design of microbial catalysts for two-stage processes

K Shabestary, S Klamt, H Link, R Mahadevan… - Nature Reviews …, 2024 - nature.com
Microbial catalysts must partition incoming substrate between the synthesis of biomass and
the synthesis of a desired product. Although biomass synthesis generates more catalyst and …

Applied evolution: Dual dynamic regulations-based approaches in engineering intracellular malonyl-CoA availability

J Wu, L Zhou, X Duan, H Peng, S Liu, Q Zhuang… - Metabolic …, 2021 - Elsevier
Malonyl-CoA is an important building block for microbial synthesis of numerous
pharmaceutically interesting or fatty acid-derived compounds including polyketides …

[HTML][HTML] Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid

A Salinas, C McGregor, V Irorere, C Arenas-López… - Metabolic …, 2022 - Elsevier
Hydroxypropionate (3-HP) is a versatile compound for chemical synthesis and a potential
building block for biodegradable polymers. Cupriavidus necator H16, a facultative …