PTEN hamartoma tumor syndrome (PTHS) includes diseases with germline pathogenic
variants in the PTEN gene. Cowden syndrome is included in this syndrome. PTEN …

Cowden syndrome is a genodermatosis with multiple hamartomatous neoplasms. With a
high incidence of breast cancer in females, this syndrome must be recognized early for …

Objective: To evaluate patients with multiple endocrine neoplasia type 1 (MEN1) for
cutaneous manifestations. Design: Survey during a 3-year period. Setting: The National …

Cowden's syndrome (CS), or multiple hamartoma syndrome, is an autosomal dominant
disorder associated with benign skin tumors and an increased risk of breast cancer. In an …

Background The spectrum of clinical findings associated withPTENtumor suppressor gene
germline mutations, referred to asPTENhamartoma-tumor syndrome (PHTS), includes …

Cowden syndrome is a rare condition defined by multiple hamartomatous growths and a
guarded prognosis owing to the high risk of cancer development. The syndrome is inherited …

Inverted follicular keratosis is characterized by a squamous epithelial expansion of the
infundibular portion of the hair follicle in an exophytic and endophytic pattern. The lesion is …

The sclerotic fibroma (SF) is a tumor of the skin that may occur sporadically or in the context
of Cowden's syndrome. The authors studied four examples of this tumor in an effort to …

CD34 antigen is expressed in normal human skin on endothelium, in spindle cells located
around adnexal structures, and in a subset of interstitial cells in the reticular dermis. CD34 …

Discussion Immunophenotyping of bone marrow allowed the confirmation of both the
diagnosis of relapse of the B-cell prolymphocytic leukaemia and of CMV infection. The …