Vulnerability of pregnant women in clinical research

ISE Van der Zande, R van der Graaf… - Journal of medical …, 2017 - jme.bmj.com
Background Notwithstanding the need to produce evidence-based knowledge on
medications for pregnant women, they remain underrepresented in clinical research …

[HTML][HTML] Fetal surgery for open spina bifida

A Sacco, F Ushakov, D Thompson… - The Obstetrician & …, 2019 - ncbi.nlm.nih.gov
Spina bifida is a congenital central nervous system malformation caused by incomplete
closure of the neural tube by 28 days of gestation, leading to a defect in the bony spine. The …

Preimplantation and prenatal diagnosis, wrongful birth and wrongful life: a global view of bioethical and legal controversies

P Frati, V Fineschi, M Di Sanzo… - Human …, 2017 - academic.oup.com
BACKGROUND Prenatal diagnosis based on different technologies is increasingly used in
developed countries and has become a common strategy in obstetric practice. The tests are …

Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic

R Ranisch, K Trettenbach, G Arnason - Medicine, Health Care and …, 2023 - Springer
Abstract Following the Second Summit on Human Gene Editing in Hong Kong in 2018,
where the birth of two girls with germline genome editing was revealed, the need for a …

Ethical, translational, and legal issues surrounding the novel adoption of ectogestative technologies

S Segers, EC Romanis - Risk management and healthcare policy, 2022 - Taylor & Francis
Increasing numbers of research teams are investigating the feasibility of developing artificial
amnion and placenta technology (AAPT), commonly referred to as “artificial womb …

Prenatal diagnosis and management of congenital diaphragmatic hernia

D Basurto, FM Russo, L Van der Veeken… - Best Practice & …, 2019 - Elsevier
Congenital diaphragmatic hernia is characterized by failed closure of the diaphragm,
thereby allowing abdominal viscera to herniate into the thoracic cavity and subsequently …

Fetal therapy for congenital hydrocephalus—where we came from and where we are going

JL Peiro, MD Fabbro - Child's Nervous System, 2020 - Springer
Despite unfavorable outcomes during the early experience with in utero intervention for
congenital hydrocephalus, improvements in prenatal diagnosis, patient selection, and fetal …

Precarious hope: Ethical considerations for offering experimental fetal therapies outside of research after initial studies in humans

S Hendriks, J Althaus, MA Atkinson… - Prenatal …, 2024 - Wiley Online Library
Objective Risks and benefits of experimental fetal therapies can remain uncertain after initial
clinical studies, especially long‐term effects. Nevertheless, pregnant individuals may …

Fetal therapy for Down syndrome: an ethical exploration

G de Wert, W Dondorp, DW Bianchi - Prenatal diagnosis, 2017 - Wiley Online Library
Background Parallel to recent advances in prenatal screening for Down syndrome (DS),
therapies for different aspects of the condition have become available. As intellectual …

Have the results of the TOTAL‐trials changed the attitude and practice of maternal‐fetal medicine specialists?

S Vergote, FM Russo, D Basurto, J Deprest… - Prenatal …, 2023 - Wiley Online Library
Objective To explore the views and practices of maternal‐fetal medicine specialists on
offering fetoscopic endoluminal tracheal occlusion (FETO) for left‐and right‐sided congenital …