Gene identity by descent (IBD) is a fundamental concept that underlies genetically mediated
similarities among relatives. Gene IBD is traced through ancestral meioses and is defined …

Advances in genotyping and sequencing technologies, coupled with the development of
sophisticated statistical methods, have afforded investigators novel opportunities to define …

Many existing cohorts contain a range of relatedness between genotyped individuals, either
by design or by chance. Haplotype estimation in such cohorts is a central step in many …

The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

This book is intended to provide fundamental statistical concepts and tools relevant to the
analysis of genetic data arising from population-based association studies. Elementary …

Whole-genome association studies present many new statistical and computational
challenges due to the large quantity of data obtained. One of these challenges is haplotype …

In this report, we compare and contrast three previously published Bayesian methods for
inferring haplotypes from genotype data in a population sample. We review the methods …

We present a statistical model for patterns of genetic variation in samples of unrelated
individuals from natural populations. This model is based on the idea that, over short …

Although many algorithms exist for estimating haplotypes from genotype data, none of them
take full account of both the decay of linkage disequilibrium (LD) with distance and the order …

We present GERMLINE, a robust algorithm for identifying segmental sharing indicative of
recent common ancestry between pairs of individuals. Unlike methods with comparable …